Abstract Title

Sensitive Electrochemical Detection of Peroxynitrite Using Bis-(4-amino-aryl)-selenide Modified Interfaces

Abstract

Azeroual Sami1, Haitham Kalil2, Mekki Bayachou2,3, and Farid Fouad4,*

1Department of Chemistry & Biochemistry, Kent State University, Kent, Ohio 44240

2Department of Chemistry, College of Science, Cleveland State University, Cleveland, Ohio 44115

3Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195

4Department of Chemistry & Biochemistry, Kent State University at East Liverpool, East Liverpool, Ohio 43920

In this work, we present the synthesis and grafting of 4,4'-diaminodiaryl selenides on graphite and indium-tin oxide electrodes for peroxynitrite sensing interfaces using voltammetry and dose-response amperometry. Modified interfaces are characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS).

The selenide modified electrodes showed a significant enhancement in peroxynitrite oxidative current compared to controls. The enhancement in peroxynitrite signal is the result of an electrocatalytic mechanism where the grafted selenide compound at the oxidized state mediates the oxidation of peroxynitrite at the electrode surface. To the best of our knowledge, this is the first time a selenium-based compound electrochemically grafted at an electrode surface is used for catalytic detection and quantification of peroxynitrite.

Modified Abstract

In this work, we present the synthesis and grafting of 4,4'-diaminodiaryl selenides on graphite and indium-tin oxide electrodes for peroxynitrite sensing interfaces using voltammetry and dose-response amperometry. Modified interfaces are characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS).

The selenide modified electrodes showed a significant enhancement in peroxynitrite oxidative current compared to controls. The enhancement in peroxynitrite signal is the result of an electrocatalytic mechanism where the grafted selenide compound at the oxidized state mediates the oxidation of peroxynitrite at the electrode surface. To the best of our knowledge, this is the first time a selenium-based compound electrochemically grafted at an electrode surface is used for catalytic detection and quantification of peroxynitrite.

Research Category

Biomedical Sciences

Author Information

Sami AzeroualFollow

Primary Author's Major

Biology

Mentor #1 Information

Dr. Farid

Fouad

Presentation Format

Poster

Start Date

April 2019

Research Area

Chemicals and Drugs | Organic Chemicals

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Apr 9th, 1:00 PM

Sensitive Electrochemical Detection of Peroxynitrite Using Bis-(4-amino-aryl)-selenide Modified Interfaces

Azeroual Sami1, Haitham Kalil2, Mekki Bayachou2,3, and Farid Fouad4,*

1Department of Chemistry & Biochemistry, Kent State University, Kent, Ohio 44240

2Department of Chemistry, College of Science, Cleveland State University, Cleveland, Ohio 44115

3Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195

4Department of Chemistry & Biochemistry, Kent State University at East Liverpool, East Liverpool, Ohio 43920

In this work, we present the synthesis and grafting of 4,4'-diaminodiaryl selenides on graphite and indium-tin oxide electrodes for peroxynitrite sensing interfaces using voltammetry and dose-response amperometry. Modified interfaces are characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and X-ray photoelectron spectroscopy (XPS).

The selenide modified electrodes showed a significant enhancement in peroxynitrite oxidative current compared to controls. The enhancement in peroxynitrite signal is the result of an electrocatalytic mechanism where the grafted selenide compound at the oxidized state mediates the oxidation of peroxynitrite at the electrode surface. To the best of our knowledge, this is the first time a selenium-based compound electrochemically grafted at an electrode surface is used for catalytic detection and quantification of peroxynitrite.