Abstract Title

Testing the Efficacy of Gallium Complexes to Treat Staphylococcus aureaus and Pseudomonas aeruginosa infections

Abstract

Bacteria in the Staphylococcus and Pseudomonas genuses have developed into antibiotic-resistant strains that have caused increases in infections and deaths in the United States. Gallium nitrate was just approved by the FDA to treat these infections; however, our group discovered that Pseudomonas develops drug resistance to this treatment in as little as four days of consecutive treatments, possibly due to the cationic nature of the gallium species and Pseudomonas control over its ion channels. In this research, we studied the effects of other gallium complexes, namely gallium acetylacetonoate, on Staphylococcus and Pseudomonas bacteria. We tried different methods of solvating gallium complexes, and then tested the effectiveness of these complexes in minimum inhibitory concentration (MIC) resistance studies.

Modified Abstract

Bacteria in the Staphylococcus and Pseudomonas genuses have developed into antibiotic-resistant strains that have caused increases in infections and deaths in the United States. Gallium nitrate was just approved by the FDA to treat these infections; however, our group discovered that Pseudomonas develops drug resistance to this treatment in as little as four days of consecutive treatments, possibly due to the cationic nature of the gallium species and Pseudomonas control over its ion channels. In this research, we studied the effects of other gallium complexes, namely gallium acetylacetonoate, on Staphylococcus and Pseudomonas bacteria. We tried different methods of solvating gallium complexes, and then tested the effectiveness of these complexes in minimum inhibitory concentration (MIC) resistance studies.

Research Category

Physics/Chemisty/Liquid Crystal

Author Information

Katherine M. GreskovichFollow

Primary Author's Major

Chemistry

Mentor #1 Information

Prof. Songping

Huang

Presentation Format

Poster

Start Date

April 2019

Research Area

Inorganic Chemistry

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Apr 9th, 1:00 PM

Testing the Efficacy of Gallium Complexes to Treat Staphylococcus aureaus and Pseudomonas aeruginosa infections

Bacteria in the Staphylococcus and Pseudomonas genuses have developed into antibiotic-resistant strains that have caused increases in infections and deaths in the United States. Gallium nitrate was just approved by the FDA to treat these infections; however, our group discovered that Pseudomonas develops drug resistance to this treatment in as little as four days of consecutive treatments, possibly due to the cationic nature of the gallium species and Pseudomonas control over its ion channels. In this research, we studied the effects of other gallium complexes, namely gallium acetylacetonoate, on Staphylococcus and Pseudomonas bacteria. We tried different methods of solvating gallium complexes, and then tested the effectiveness of these complexes in minimum inhibitory concentration (MIC) resistance studies.