1. Open Access Kent State
  2. Sex Differences in the Generalization of Fear as a Function of Retention Intervals
Author(s)
Abstract

In previous studies using male rodents, context change disrupted a fear response at a short, but not a long, retention interval. Here, we examined the effects of context changes on fear responses as a function of time in male and female rats. Males displayed context discrimination at all intervals, whereas females exhibited generalization by 5 d. Ovariectomized females with no hormone replacement displayed context discrimination at 5 d, whereas those receiving 17β-estradiol generalized their fear response to a neutral context. These results demonstrate that fear generalization for contextual cues occurs faster in female rats and is mediated, in part, by estrogens.
Format
Article
Identifier(s)
10.1101/lm.032011.113
Publication Date
2013-11-01
Publication Title
Learning and Memory
Volume
20
Issue
11
First Page
628
Last Page
632
Keywords
Subject
Rights
http://rightsstatements.org/vocab/InC/1.0/
Community
Department of Psychological Sciences
Permalink https://oaks.kent.edu/psycpubs/7
Lynch, J., Cullen, P., Jasnow, A., & Riccio, D. (2013). Sex Differences in the Generalization of Fear as a Function of Retention Intervals (1–). Learning and Memory. https://doi.org/10.1101/lm.032011.113
Lynch, Joseph, Patrick Cullen, Aaron Jasnow, and David Riccio. 2013. “Sex Differences in the Generalization of Fear As a Function of Retention Intervals”. Learning and Memory. https://doi.org/10.1101/lm.032011.113.
Lynch, Joseph, et al. Sex Differences in the Generalization of Fear As a Function of Retention Intervals. Learning and Memory, 1 Nov. 2013, https://doi.org/10.1101/lm.032011.113.