Comparative Spectrophotometrc Analysis of Rifampicin by Chelate Formation and Charge-Transfer Complexation
rifampicin, cupric ion, chelate, halogenated quinones, charge-transfer complex, capsules, urine analysis
Biochemistry | Chemistry | Medical Biochemistry | Medicinal and Pharmaceutical Chemistry
Simple, rapid, and accurate spectrophotometrc procedures for the determination of the antibiotic rifampicin, in capsules, are presented. A chelate formation of the antibiotic with cupric ion and charge-transfer complexation with halogenated quinones are carried out. Linear correlations between absorbance and concentration over the range of 40-100 μg ml−1 were computed. The reaction pathways were proposed. The utility of copper chelate as a stability indicating procedure as well as a method to determine rifampicin In spiked urine samples is demonstrated.
Galal, Shereen M.; Blaih, Salah; and Abdel-Hamid, Mohamed E. (1992). Comparative Spectrophotometrc Analysis of Rifampicin by Chelate Formation and Charge-Transfer Complexation. Analytical Letters 25(4), 725-743. doi: 10.1080/00032719208020030 Retrieved from https://digitalcommons.kent.edu/chempubs/37