Title

Comparative Spectrophotometrc Analysis of Rifampicin by Chelate Formation and Charge-Transfer Complexation

Publication Title

Analytical Letters

Publication Date

4-1992

Document Type

Article

DOI

10.1080/00032719208020030

Keywords

rifampicin, cupric ion, chelate, halogenated quinones, charge-transfer complex, capsules, urine analysis

Disciplines

Biochemistry | Chemistry | Medical Biochemistry | Medicinal and Pharmaceutical Chemistry

Abstract

Simple, rapid, and accurate spectrophotometrc procedures for the determination of the antibiotic rifampicin, in capsules, are presented. A chelate formation of the antibiotic with cupric ion and charge-transfer complexation with halogenated quinones are carried out. Linear correlations between absorbance and concentration over the range of 40-100 μg ml−1 were computed. The reaction pathways were proposed. The utility of copper chelate as a stability indicating procedure as well as a method to determine rifampicin In spiked urine samples is demonstrated.

Publisher

Taylor & Francis

Publisher Location

Philadelphia, PA


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