Title

Spectrophotometric Determination of Acrivastine in Urine and Capsules

Publication Title

Talanta

Publication Date

10-1996

Document Type

Article

DOI

10.1016/0039-9140(96)01901-7

Keywords

acrivastine, derivative spectrophotometry, urine

Disciplines

Allergy and Immunology | Analytical, Diagnostic and Therapeutic Techniques and Equipment | Chemicals and Drugs | Chemistry | Medicinal and Pharmaceutical Chemistry

Abstract

Three sensitive and accurate spectrophotometric methods are presented for the determination of the antihistaminic acrivastine (ACR) in capsules and urine. The first method utilizes the reaction of 2-nitrophenylhydrazine hydrochloride in presence of dicyclohexylcarbodiimide and pyridine. The violet colour of the resulting acid hydrazide is measured at 550 nm. The second method is based on alkaline oxidation of the drug with potassium permanganate and subsequent measurement of the formed manganate ion at 608 nm. The third method uses derivative spectrophotometry for the determination of ACR. The last method is extended to the in vitro determination of the drug in urine. All methods gave a relative standard deviation of less than 2%.

Publisher

Elsevier


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