1. Open Access Kent State
  2. Spectrophotometric Determination of Acrivastine in Urine and Capsules
Author(s)
Abstract

Three sensitive and accurate spectrophotometric methods are presented for the determination of the antihistaminic acrivastine (ACR) in capsules and urine. The first method utilizes the reaction of 2-nitrophenylhydrazine hydrochloride in presence of dicyclohexylcarbodiimide and pyridine. The violet colour of the resulting acid hydrazide is measured at 550 nm. The second method is based on alkaline oxidation of the drug with potassium permanganate and subsequent measurement of the formed manganate ion at 608 nm. The third method uses derivative spectrophotometry for the determination of ACR. The last method is extended to the in vitro determination of the drug in urine. All methods gave a relative standard deviation of less than 2%.
Format
Article
Identifier(s)
10.1016/0039-9140(96)01901-7
Publication Date
1996-10-01
Publication Title
Talanta
Volume
43
Issue
10
First Page
1643
Last Page
1648
Keywords
Subject
Rights
http://rightsstatements.org/vocab/InC/1.0/
Community
Department of Chemistry & Biochemistry
Permalink https://oaks.kent.edu/chempubs/34
Abdine, H., Gazy, A., Blaih, S., & Korany, M. (1996). Spectrophotometric Determination of Acrivastine in Urine and Capsules (1–). Talanta. https://doi.org/10.1016/0039-9140(96)01901-7
Abdine, Heba, Azza Gazy, Salah Blaih, and Mohamed Korany. 1996. “Spectrophotometric Determination of Acrivastine in Urine and Capsules”. Talanta. https://doi.org/10.1016/0039-9140(96)01901-7.
Abdine, Heba, et al. Spectrophotometric Determination of Acrivastine in Urine and Capsules. Talanta, 1 Oct. 1996, https://doi.org/10.1016/0039-9140(96)01901-7.