Author(s) | |
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Abstract |
We assessed the effect of a cholinergic challenge on serial pattern extrapolation in rats. Male and female rats learned a rule-based serial pattern of nosepoke responses in receptacles on the walls of an octagonal operant chamber. The training pattern consisted of 7 chunks of a rule-based serial pattern (123-234-345-456-567-678-781). After learning to a criterion of 90% correct responses on all elements of the pattern, rats were given i.p. injections of 0.6 mg/kg scopolamine hydrobromide 30 minutes before testing on a transfer pattern consisting of the training pattern with an added eighth chunk that was either consistent with pattern structure (chunk “812”) or contained a terminal element that violated pattern structure (chunk “818”). Under scopolamine, and even with impaired performance throughout the pattern, rats in both groups extrapolated known pattern structure, producing approximately 60% rule-consistent responses on the terminal element of both added chunks. Despite scopolamine exposure, both male and female rats extrapolated well-learned pattern structure to a new chunk. In the case of the chunk containing the violation element, when confronted with a new trial requiring a response inconsistent with already learned pattern structure, rats attempted to apply the well-learned rule. |
Format | |
Publication Date |
2017-03-21
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Contributor(s) |
Faculty Mentor
Mrs. Megan E. Miller Cahill Ms. Jessica L. Sharp
Dr. Stephen B. Fountain
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Subject | |
Modified Abstract |
Rats learned a rule-based serial pattern that consisted of seven chunks (123-234-345-456-567-678-781). After learning to a high criterion on all elements of the pattern, rats were given injections of scopolamine 30 minutes before testing on a transfer pattern consisting of the training pattern with an added eighth chunk that was either consistent with pattern structure (chunk “812”) or contained a terminal element that violated pattern structure (chunk “818”). Under scopolamine, rats in both groups extrapolated known pattern structure, producing rule-consistent responses on the terminal element of both added chunks. In the case of the chunk containing the violation element, when confronted with a new trial requiring a response inconsistent with already learned pattern structure, rats attempted to apply the well-learned rule. |
Permalink | https://oaks.kent.edu/ugresearch/2017/psychology/5 |
Serial Pattern Extrapolation is Spared during a Cholinergic Challenge in Rats
Hasso, N., Miller, M., Sharp, J., & Fountain, S. (2017). Serial Pattern Extrapolation is Spared during a Cholinergic Challenge in Rats (1–). https://oaks.kent.edu/node/5524
Hasso, Nathaniel, Megan Miller, Jessica Sharp, and Stephen Fountain. 2017. “Serial Pattern Extrapolation Is Spared During a Cholinergic Challenge in Rats”. https://oaks.kent.edu/node/5524.
Hasso, Nathaniel, et al. Serial Pattern Extrapolation Is Spared During a Cholinergic Challenge in Rats. 21 Mar. 2017, https://oaks.kent.edu/node/5524.