Abstract Title

Discovery of small molecular inhibitors of ribosomal assembly

Abstract

In recent years there has been a drastic increase in resistance to existing antibiotics. Centers for Disease Control and Prevention (CDC) estimates extra 20 million expenditure combat antibiotic resistance in bacteria. To combat antibacterial resistance new antibiotic targets and new drugs that bind to existing target need to be discovered. My project in Abeysirigunawardena research laboratory looks at various strategies to successfully disrupt ribosome assembly using various small molecules and currently known antibiotics. We hypothesized that disruption of RNS-protein interactions of the early binding ribosomal protein S4 and 16S RNA will efficiently inhibit the ribosome assembly hence can be successfully used as new antibiotic target. I am currently developing fluorescence-based assays to detect inhibition of S4 binding. We are confident that these efforts lead better antibiotics.

Modified Abstract

In recent years there has been a drastic increase in resistance to existing antibiotics. Centers for Disease Control and Prevention (CDC) estimates extra 20 million expenditure combat antibiotic resistance in bacteria. To combat antibacterial resistance new antibiotic targets and new drugs that bind to existing target need to be discovered. My project in Abeysirigunawardena research laboratory looks at various strategies to successfully disrupt ribosome assembly using various small molecules and currently known antibiotics. We hypothesized that disruption of RNS-protein interactions of the early binding ribosomal protein S4 and 16S RNA will efficiently inhibit the ribosome assembly hence can be successfully used as new antibiotic target. I am currently developing fluorescence-based assays to detect inhibition of S4 binding. We are confident that these efforts lead better antibiotics.

Research Category

Biomedical Sciences

Primary Author's Major

Pre-Pharmacy

Mentor #1 Information

Sanjaya Abeysirigunawardena

Presentation Format

Poster

Start Date

March 2016

Research Area

Alternative and Complementary Medicine

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Mar 15th, 1:00 PM

Discovery of small molecular inhibitors of ribosomal assembly

In recent years there has been a drastic increase in resistance to existing antibiotics. Centers for Disease Control and Prevention (CDC) estimates extra 20 million expenditure combat antibiotic resistance in bacteria. To combat antibacterial resistance new antibiotic targets and new drugs that bind to existing target need to be discovered. My project in Abeysirigunawardena research laboratory looks at various strategies to successfully disrupt ribosome assembly using various small molecules and currently known antibiotics. We hypothesized that disruption of RNS-protein interactions of the early binding ribosomal protein S4 and 16S RNA will efficiently inhibit the ribosome assembly hence can be successfully used as new antibiotic target. I am currently developing fluorescence-based assays to detect inhibition of S4 binding. We are confident that these efforts lead better antibiotics.