Abstract Title

Synthesis of Photoactivatable HNO Donors

Abstract

HNO (nitroxyl) is a biologically relevant unstable small molecule which rapidly dimerizes in aqueous solution. Thus, there is a need for HNO donors that can quickly release HNO “on demand”. Our group has developed a first generation family of HNO donors which generate HNO rapidly through photolysis. However, some competition from a photoredox side reaction reduces the utility of these molecules. The goal of this project was to explore the impact of incorporating a methyl substituent on the rate and selectivity of HNO generation. The poster will describe the studies completed to date on the synthesis and photochemistry of HNO donor.

Research Category

Physics/Chemisty/Liquid Crystal

Primary Author's Major

Biochemistry

Mentor #1 Information

Dr. Paul Sampson

Mentor #2 Information

Dr. Alexander J Seed

Mentor #3 Information

Dr. Nicola E Brasch

Mentor #4 Information

Yang Zhou

Presentation Format

Poster

Start Date

11-3-2015 1:00 PM

End Date

11-3-2015 5:00 PM

Research Area

Chemistry | Organic Chemistry | Physical Sciences and Mathematics

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Mar 11th, 1:00 PM Mar 11th, 5:00 PM

Synthesis of Photoactivatable HNO Donors

HNO (nitroxyl) is a biologically relevant unstable small molecule which rapidly dimerizes in aqueous solution. Thus, there is a need for HNO donors that can quickly release HNO “on demand”. Our group has developed a first generation family of HNO donors which generate HNO rapidly through photolysis. However, some competition from a photoredox side reaction reduces the utility of these molecules. The goal of this project was to explore the impact of incorporating a methyl substituent on the rate and selectivity of HNO generation. The poster will describe the studies completed to date on the synthesis and photochemistry of HNO donor.