Publication Title

Learning and Memory

Publication Date

4-2014

Document Type

Article

DOI

10.1101/lm.032961.113.

Keywords

GABA, presynaptic inhibition, precision, long-term memory

Disciplines

Other Psychiatry and Psychology | Psychiatry and Psychology | Psychological Phenomena and Processes

Abstract

Though much attention has been given to the neural structures that underlie the long-term consolidation of contextual memories, little is known about the mechanisms responsible for the maintenance of memory precision. Here, we demonstrate a rapid time-dependent decline in memory precision in GABAB(1a) receptor knockout mice. First, we show that GABAB(1a) receptors are required for the maintenance, but not encoding, of a precise fear memory. We then demonstrate that GABAB(1a) receptors are required for the maintenance, but not encoding, of spatial memories. Our findings suggest that GABA-mediated presynaptic inhibition regulates the maintenance of memory precision as a function of memory age.

Publisher

Cold Spring Harbor Laboratory Press


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