Publication Title

Physical Review E

Publication Date

2-18-2005

Document Type

Article

DOI

10.1103/PhysRevE.71.020702

Keywords

ligand-receptor binding, cells

Disciplines

Physics

Abstract

We describe director distortions in the nematic liquid crystal (LC) caused by a spherical particle with tangential surface orientation of the director and show that light transmittance through the distorted region is a steep function of the particle's size. The effect allows us to propose a real-time microbial sensor based on a nontoxic lyotropic chromonic LC (LCLC) that detects and amplifies the presence of immune complexes. A cassette is filled with LCLC, antibody, and antigen-bearing particles. Small and isolated particles cause no macroscopic distortions of the LCLC. Upon antibody-antigen binding, the growing immune complexes distort the director and cause detectable optical transmittance between crossed polarizers.

Comments

Copyright 2005 American Physical Society. Available on publisher's site at http://dx.doi.org/10.1103/PhysRevE.71.020702


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