International Journal of Nanomedicine
magnetic nanoparticles, oxidative stress, brain, cytotoxicity, aggregation, delivery, neurons
Background: Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the biocompatibility and uptake characteristics of AmS-IONPs in central nervous system (CNS)-relevant cells are unknown. The purpose of this study was to determine the effect of surface charge and magnetic field on toxicity and uptake of AmS-IONPs in CNS-relevant cell types.
Sun, Zhizhi; Yathindranath, Vinith; Worden, Matthew; Thliveris, James A.; Chu, Stephanie; Parkinson, Fiona E.; Hegmann, Torsten; and Miller, Donald W. (2013). Characterization of Cellular Uptake and Toxicity of Aminosilane-Coated Iron Oxide Nanoparticles with Different Charges in Central Nervous System-Relevant Cell Culture Models. International Journal of Nanomedicine 8, 961-970. doi: 10.2147/IJN.S39048 Retrieved from http://digitalcommons.kent.edu/cpippubs/154