Publication Title

International Journal of Nanomedicine

Publication Date

3-6-2013

Document Type

Article

DOI

10.2147/IJN.S39048

Keywords

magnetic nanoparticles, oxidative stress, brain, cytotoxicity, aggregation, delivery, neurons

Disciplines

Physics

Abstract

Background: Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the biocompatibility and uptake characteristics of AmS-IONPs in central nervous system (CNS)-relevant cells are unknown. The purpose of this study was to determine the effect of surface charge and magnetic field on toxicity and uptake of AmS-IONPs in CNS-relevant cell types.

Comments

Originally published in International Journal of Nanomedicine by Dove Medical Press. Available on publisher's site at http://dx.doi.org/10.2147/IJN.S39048.


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